Burnout is one of the effective factors in reducing staff performance quality. Stress and burnout lead to quitting the job in the nursing profession to a great extent. Considering the importance of the nurses' physical and mental health and the role of burnout in nursing services quality, the present research aimed to investigate the relationship between the antecedents and burnout among the staff nurses working in hospitals of Shiraz. The research population included 2016 nurses working in the hospitals of Shiraz, of whom 322 were selected through stratified random sampling. The study data were collected using burnout1 and NBS2 questionnaires and analyzed using descriptive statistics (mean, variance) as well as inferential statistics (correlation coefficient, variance analysis). The results showed that antecedents (responsibility, work load, lack of community, and supervision) had a significant direct relationship with burnout. Therefore, antecedents cause stress and tension in the work environment and finally cause burnout in nurses.
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