Organizational politics plays a large role in how most businesses function and develop. Humans are political animals so it is difficult to prevent politics from the work place. Organizational politics have so many influences on the affairs and behavior of employees in an organization. However, there has been limited study in this area in Ghana specifically and Africa as a whole. The purpose of this study was to examine the influence of organizational politics on business entities within Accra metropolis, Ghana. Two large business organizations were chosen within the metropolis. In addition, forty (40) questionnaires were distributed to forty (40) respondents thus; twenty (20) for each organizational setup. It was concluded that political factors such as increase anxiety and stress, create hostile organizational environment and climate of mistrust were dominant negative political influences on organizations. The researchers recommended both management and employees to set aside their personal interests and go along with the mission of the organization for the achievement of stated goals.
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