This study focused on the influence of knowledge management and innovation of teaching and learning activities in Malaysian institutes of teacher education. A cross-sectional survey design was used to collect the data from 100 randomly selected respondents. The respondents were academic lecturers from the teacher education institutes within southern Malaysia. Closed-ended questionnaires using five point Likert scale were used to collect the primary data from all the 100 respondents. The collected data were analyzed using SPSS Software Version 22.0. The Pearson’s correlation coefficient was used to test the existence of relationship between knowledge management and innovation of teaching and learning activities. The findings revealed that knowledge management was significant in enhancing innovation of teaching and learning activities. Knowledge management had a moderate but positive linear relationship as proved statistically by a correlation coefficient value of 0.624. The results indicated that a rise in knowledge management practices create more opportunities for the lecturers to enhance innovations in teaching and learning activities. Therefore, the researcher recommends a comprehensive module outlining knowledge management processes should be circulated and innovative leaders needed in guiding the lecturers in executing the practice widely in teacher education institutes.
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