Obesity is usually accompanied by excess presence of adipose tissue in the body which could cause excess xanthine oxidoreductase (XOR) production. Uric acid levels can increase with an excess of XOR production. Increased body fat also promotes fat deposition in the liver. Excess fat deposition induces the release of abundant reactive oxygen species (ROS) resulting in oxidative stress. Thus, this promotes an increase in serum gamma-glutamyltranspeptidase (GGT) level, which has potential anti-oxidative stress properties. This study aimed to identify the changes on serum uric acid and GGT level with association to waist to hip ratio (WHR) circumference in obese and non-obese individuals. A total number of 30 individuals aged between 20-45 years old participated. Data was analyzed using Mann Whitney U test and Spearman’s rho test which was considered statistically significant at P<0.05. The variables in both male and female obese and non-obese individuals, the result shows significant, positive correlation even though all the variables showed positive correlation for both groups of obese and non-obese individuals, the strength of the relationship in obese individuals was much stronger than non-obese individuals. In the conclusion, increment of serum uric acid and GGT level were related with increased value of BMI and WHR as shown in previous studies.
Achike, F. I., To, N. H. P., Wang, H., & Kwan, C. Y. (2011). Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clinical and Experimental Pharmacology and Physiology, 38, 1–10.
Afzali, A., Weiss, N. S., Boyko, E. J., & Ioannou, G. N. (2010). Association between serum uric acid level and chronic liver disease in the United States. Hepatology, 52, 578–589.
Azmi, M. Y., Junidah, R., Mariam, A. S., Safiah, M. Y., Fatimah, S., Norimah, A. K., ... & Haslinda, M. D. (2009). Body mass index (BMI) of adults: findings of the Malaysian Adult Nutrition Survey (MANS). Malaysian journal of nutrition, 15(2).
Cai, W., Wu, X., Zhang, B., Miao, L., Sun, Y., Zou, Y., & Yao, H. (2013). Serum uric acid levels and non- alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China.
Choi, J. W. (2003). Association between elevated serum hepatic enzyme activity and total body fat in obese humans. Annals of Clinical and Laboratory Science, 33, 257–264.
Collins, J., & Bentz, J. E. (2009). Behavioral and psychological factors in obesity. The Journal of Lancaster General Hospital, 4(4).
Das, A. K., Chandra, P., Gupta, A., & Ahmad, N. (2014). Obesity and the levels of liver enzymes (ALT, AST & GGT) in East Medinipur, India. Asian Journal of Medical Sciences (E-ISSN 2091-0576; P-ISSN 2467-9100), 6(1), 40-42.
Dasgupta, A. (2012). Science of drinking: Alcohol use, abuse and alcohol biomarkers.
De Oliveira, E. P., & Burini, R. C. (2012). High plasma uric acid concentration: causes and consequences. Diabetology & Metabolic Syndrome, 4, 12.
Després, J. P. (2012). Body fat distribution and risk of cardiovascular disease: An update. Circulation, 126, 1301–1313.
Eguchi, Y., Eguchi, T., Mizuta, T., Ide, Y., Yasutake, T., Iwakiri, R., ... & Kawaguchi, Y. (2006). Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. Journal of gastroenterology, 41(5), 462-469.
Ezzat, W. M., Ragab, S., Ismail, N. A., Elhosary, Y. A., ElBaky, A. M. N. E. A., Farouk, H., & Rasheed, I. A. (2012). Frequency of non-alcoholic fatty liver disease in overweight/obese children and adults: Clinical, sonographic picture and biochemical assessment. Journal of Genetic Engineering and Biotechnology, 10(2), 221-227.
Gandhi, R., Dhotar, H., Tsvetkov, D., & Mahomed, N. N. (2010). The relation between body mass index and waist-hip ratio in knee osteoarthritis. Canadian Journal of Surgery., 53, 151–154.
Gowda, S., Desai, P. B., Hull, V. V, Math, A. a K., Vernekar, S. N., & Kulkarni, S. S. (2009). A review on laboratory liver function tests. The Pan African Medical Journal, 3, 17.
Hikita, M., Ohno, I., Mori, Y., Ichida, K., Yokose, T., & Hosoya, T. (2007). Relationship between hyperuricemia and body fat distribution. Internal Medicine (Tokyo, Japan), 46, 1353–1358.
Hossain, P., Kawar, B., & El Nahas, M. (2007). Obesity and diabetes in the developing world: a growing challenge. New England Journal of Medicine, 356, 213–215.
Jakobsen, M. U., Berentzen, T., Sørensen, T. I. A., & Overvad, K. (2007). Abdominal obesity and fatty liver. Epidemiologic Reviews, 29, 77–87.
Janssen, I.,Katzmarzyk, P. T., & Ross, R. (2004). Waist circumference and not body mass index explains obesity-related health risk. The American journal of clinical nutrition, 79(3), 379-384.
Kantartzis, K., & Stefan, N. (2012). Cardiovascular disease in patients with non-alcoholic fatty liver disease. Annals of Gastroenterology, 25(3), 276.
Karakurt, F., Maral, S., Lu, B. K. ?., & Darcin, T. (2011). Serum Uric Acid Levels in Obese Women. Yeni T?p Dergisi, 28(1), 34.
Khullar, K., Agarwal, A., & du Plessis, S. S. (2014). BMI and Obesity. InMale Infertility (pp. 31-45). Springer New York.
Krishnamurthy, H. A. (2013). The serum gamma glutamyl transpeptidase - A non invasive diagnostic bio marker of chronic anicteric non alcoholic liver diseases. Journal of Clinical and Diagnostic Research, 7, 691–694.
Kong, A. P. S., Choi, K. C., Ho, C. S., Chan, M. H. M., Ozaki, R., Chan, C. W. H., & Chan, J. C. N. (2013). Associations of uric acid and gamma?glutamyltransferase (GGT) with obesity and components of metabolic syndrome in children and adolescents. Pediatric obesity, 8(5), 351-357.
Kunutsor, S. K., Apekey, T. A., & Walley, J. (2013). Liver aminotransferases and risk of incident type 2 diabetes: A systematic review and meta-analysis. American Journal of Epidemiology, 178, 159–171.
Latha, P. J.,Ganesan, S., Biochemistry, A., College, T. M., R, T. T. M. G., & Latha, P. J. (2015). Correlation of Serum Gamma Glutamyl Transferase with Atherogenic Dyslipidemia in Obese Individuals. Scholars Journal of Applied Medical Sciences (SJAMS), 3, 387–391.
Li, C., Hsieh, M.-C., & Chang, S.-J. (2013). Metabolic syndrome, diabetes, and hyperuricemia. Current Opinion in Rheumatology, 25, 210–216.
Lokuruka, M. N. I. (2013). A literature review of role of obesity in adult health with reference to Africa. African Journal of Food, Agriculture, Nutrition and Development, 13, 7088–7104.
Luo, M., Li, Z. Z., Li, Y. Y., Chen, L. Z., Yan, S. P., Chen, P., & Hu, Y. Y. (2014). Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension. Scientific Reports, 4, 7291.
Muralidhara, D., US, M., & Swethadri, G. (2012). An Update on the variants of obesity. Journal of Pharmaceutical and Biomedical Sciences, 16.
Nazaimoon, W., Mohamud, W., Musa, K. I., Sharifuddin, A., Frcp, K., Ismail, A., … Mrcp, I. (2011). Short Communication Prevalence of overweight and obesity among adult Malaysians?: an update, 20, 35–41.
Nemesure, B., Yuh Wu, S., Hennis, A., & Cristina Leske, M. (2008). The Relationship of BMI and WHR on the 9-Year Incidence of Type 2 Diabetes and Hypertension in a Predominantly African-origin Population. Ann Epidemiol, 18, 657–663.
Niranjan, G., Ajeet, S., Srinivasan, A. R., Saha, S., & Prakash, H. M. (2012). Serum Gamma Glutamyl Transferase levels in Obese South Indian adults with reference to atherogenic lipid risk factors and lipid peroxides. Int. J. Med. Health Sci, 1(2), 35-42.
N, S. K., M, A. K., Shetty, S., Bhandary, R. R., & Kathyayini. (2011). Serum uric acid as obesity related indicator in young obese adults. Research Journal of Pharmaceutical , Biological and Chemical Sciences, 2.
Oyama, C., Takahashi, T., Oyamada, M., Oyamada, T., Ohno, T., Miyashita, M., … Takada, G. (2006). Serum uric acid as an obesity-related indicator in early adolescence. The Tohoku Journal of Experimental Medicine, 209, 257–262.
Pasalic, D., Marinkovic, N., & Feher-turkovic, L. (2012). Uric acid as one of the important factors in multifactorial disorders – facts and controversies. Biochemia Medica, 22, 1–8.
Puukka, K., Hietala, J., Koivisto, H., Anttila, P., Bloigu, R., & Niemelä, O. (2006). Additive effects of moderate drinking and obesity on serum ?-glutamyl transferase activity. The American journal of clinical nutrition, 83(6), 1351-1354.
Ramachandran, A., & Snehalatha, C. (2010). Rising Burden of Obesity in Asia. Journal of Obesity, 8.
Ruttmann, E., Brant, L. J., Concin, H., Diem, G., Rapp, K., & Ulmer, H. (2005). ?-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality. An Epidemiological Investigation in a Cohort of 163 944 Austrian Adults. Circulation, 112(14), 2130-2137.
Ryu, S., Chang, Y., Zhang, Y., Kim, S. G., Cho, J., Son, H. J., … Guallar, E. (2011). A cohort study of hyperuricemia in middle-aged South Korean men. American Journal of Epidemiology, 175, 133–143.
Sanya, A., Ogwumike, O., Ige, A., & Ayanniyi, O. (2009). Relationship of Waist-Hip Ratio and Body Mass Index to Blood Pressure of Individuals in Ibadan North Local Government. African Journal of Physiotherapy and Rehabilitation Sciences, 1, 7–11.
So, A., & Thorens, B. (2010). Uric acid transport and disease. The Journal of clinical investigation, 120(6), 1791-1799.
Stranges, S., Dorn, J. M., Muti, P., Freudenheim, J. L., Farinaro, E., Russell, M.,... & Trevisan, M. (2004). Body fat distribution, relative weight, and liver enzyme levels: A population?based study. Hepatology, 39(3), 754-763.
Suter, P. M., & Tremblay, A. (2005). Is alcohol consumption a risk factor for weight gain and obesity. Critical reviews in clinical laboratory sciences, 42(3), 197-227.
Teo, P. S., Nurul-Fadhilah, A., Aziz, M. E., Hills, A. P., & Foo, L. H. (2014). Lifestyle practices and obesity in Malaysian adolescents. International Journal of Environmental Research and Public Health, 11, 5828–5838.
Tsushima, Y., Nishizawa, H., Tochino, Y., Nakatsuji, H., Sekimoto, R., Nagao, H.,... & Tamura, M. (2013). Uric acid secretion from adipose tissue and its increase in obesity. Journal of Biological Chemistry, 288(38), 27138-27149.
Vazquez, G., Duval, S., Jacobs, D. R., & Silventoinen, K. (2007). Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: A meta-analysis. Epidemiologic Reviews, 29, 115–128.
Wellness Talk. (2013). Golden Horses Health Sanctuary. Retrieved from www.ghhs.com.my
Wu, J., Qiu, L., Yan, W., Cheng, X., Wu, W., Guo, X., … Zhu, G. (2013). Serum gamma-glutamyltransferase and uric acid levels are associated with impaired fasting glucose in adults from Inner Mongolia, China. BMC Public Health, 13.
World Health Organization, G. (1998). Obesity preventing and managing the global epidemic.
Yadav, B. K., Chhetri, G. B., Poudel, B., Sigdel, M., & Gyawali, P. (2009). Serum Uric Acid Level in Obese and Non-obese Individuals Serum Uric Acid Level in Obese and Non-obese Individuals, 10.
Zapolski, T., Wacinski, P., Kondracki, B., Rychta, E., Buraczynska, M. J., & Wysokinski, A. (2011). Uric acid as a link between renal dysfunction and both pro-inflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. Kardiologia Polska, 69, 319–326.
Zhang, J., Zhang, Y., Deng, W., & Chen, B. (2014). Elevated serum uric acid is associated with angiotensinogen in obese patients with untreated hypertension. J Clin Hypertens (Greenwich), 16, 569–574.
Zheng, R. D., Chen, Z. R., Chen, J. N., Lu, Y. H., & Chen, J. (2012). Role of body mass index, waist-to-height and waist-to hip ratio in prediction of non-alcoholic fatty liver disease. Gastroenterology research and practice.
Yunus, Y. M., Muniandy, W., & Lai, H. I. (2017). Comparison of Serum Uric Acid and Gamma-Glutamyltranspeptidase (GGT) Level in Obese Individuals and Non-Obese Individual. International Journal of Academic Research in Business and Social Sciences, 7(3), 702-713.
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