Using socio-scientific issues (SSI) in science lesson especially biology is an approach for students to understand and empower the science concept. Students are given the opportunity to argue the issues and will improve the process of reasoning. Using this approach indirectly can create awareness of ethics and problem solving to students. From the literature review hopefully can develop reasoning skills model based on SSI. Structural Equation Model (SEM) approach is used for measure and identify the variables that contribute students’ reasoning skills. From trends of literature reviews, three independents variables were identified, Content Acquisition, Epistemology Science Belief, Adhered values and ethics towards Reasoning Skills as a dependent variable. Hoped this study will help to improve the empowering of science concepts and Higher Order Thinking Skills (HOTS). In another hand, it also can produce a holistic students and increase creative and critical thinking skill while using the model of reasoning as a guideline.
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