Entrepreneurship currently is seen worldwide or globally as an efficient and effective vehicle for socio-economic growth and sustainable development. Most governments have it as a core part of their programme of governance and also committed considerable amount of resources to it, as a result of high rate of unemployment with the object of encouraging graduates after school to establish themselves and become their own bosses, instead of seeking to be employed which is non-existent. The current study seeks to analyse barriers to start-up business among graphic design graduates, Takoradi Polytechnic. The study employed survey and descriptive research method in executing the study. Data analysed in the paper revealed that; a considerable number of graphic design graduates from takoradi polytechnic were not employed after six years of graduation, majority had nursed the intention of establishing their own business ventures, the graduates preferred sole proprietorship and printing as their choice of form and type of business to pursue, they also had a great deal of knowledge on entrepreneurial agencies and support services but were ignorant of what they had to offer new and existing entrepreneurs and finally, lack of government support and funding were the significant barriers graphic design students come face to face with in the bid to establish themselves.
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