Background: Metabolic Syndrome (MetS) in adolescence is a growing public health concern. This study aimed to evaluate the effects of an eight-week multicomponent intervention program (MIP) on MetS criteria and health-related fitness (HRF) components among adolescents with obesity aged 13–16 years in Al Batinah South Governorate, Sultanate of Oman. Methods: Thirty-two adolescents diagnosed with MetS were randomly assigned to either the MIP group or a control group. The MIP included nutritional counseling, parental involvement, and a structured physical activity regimen over eight weeks. Anthropometric data, blood pressure, fasting glucose, lipid profiles, and HRF parameters were assessed pre- and post-intervention. Results: Post-intervention, the MIP group showed significant improvements in BMI, waist circumference, systolic and diastolic blood pressure, fasting glucose, and HDL-C. Cardiorespiratory fitness and muscular endurance also improved significantly, while flexibility and triglycerides showed no significant change. Large effect sizes were observed for BMI (?² = 0.921), systolic BP (?² = 0.941), and fasting glucose (?² = 0.848), indicating substantial clinical relevance. No significant improvements were noted in the control group. Conclusion: An eight-week school-based MIP led to significant improvements in metabolic health and physical fitness among male adolescents with obesity. Incorporating such programs into the school curriculum may offer an effective strategy for managing obesity.
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