This study explores the concept of strategic supremacy for business organizations in developing countries and argues that achieving true economic independence is impossible without dismantling neocolonial structures. Neocolonialism continues to manifest through economic dependency, corporate dominance, and geopolitical control, keeping developing nations subordinate to global economic powers. Multinational corporations (MNCs), international financial institutions, and unfair trade policies reinforce economic hierarchies, preventing developing economies from achieving self-sufficiency. By integrating Dependency Theory, World-Systems Theory, and Sustainable Development Theory, this research highlights the mechanisms through which neocolonialism persists and provides a strategic framework for breaking free from these constraints. It advocates for reducing reliance on foreign capital and technology, fostering regional cooperation, diversifying economies, and investing in local innovation as essential steps toward economic sovereignty. Additionally, good governance, institutional reforms, and corporate social responsibility (CSR) are identified as critical factors in ensuring long-term sustainable development. Case studies from Malaysia, Vietnam, Kenya, illustrate successful efforts toward economic diversification and technological advancement, offering valuable insights for developing nations seeking to break free from external control. However, the study concludes that strategic supremacy cannot be fully achieved without actively resisting and dismantling neocolonialism. To establish a self-sustaining economic order, developing nations must challenge exploitative financial systems, reform global trade structures, and build strong regional alliances. Only through true economic liberation can developing countries secure their place as independent, competitive forces in the global economy.
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