Research integrity serves as the foundation of trust and transparency in the academic world, yet challenges such as data manipulation, plagiarism, and conflicts of interest continue to threaten the credibility of research outcomes. Islamic values such as trustworthiness and responsibility, as highlighted in Surah Al-Mu’minun (23:8-9), offer a holistic moral framework to address these issues. Trustworthiness ensures researchers act with honesty and transparency during data collection, analysis, and reporting, while responsibility requires consideration of social impacts and prioritization of societal well-being. This study adopts a qualitative approach, analyzing Quranic texts, prophetic traditions (hadith), and prominent exegeses, such as Tafsir Ibn Kathir, alongside international research ethics guidelines, including the Singapore Statement on Research Integrity and the European Code of Conduct. Case studies, such as the Thalidomide tragedy and the Tuskegee Syphilis Study, are examined to illustrate the severe consequences of disregarding moral principles. The findings suggest that Islamic values complement modern ethical standards by strengthening moral and spiritual dimensions. Supplementary principles such as ihsan (pursuit of excellence) and taqwa (spiritual awareness) further enhance research integrity. As a Muslim-majority country, Malaysia holds significant potential to lead the integration of Islamic values into its national research ethics framework. This integration not only strengthens public trust in research but also provides a model to address global challenges, including technological advancements and commercialization. The question remains: how effectively can these values be implemented in a research environment shaped by the pressures of globalization
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