Depression, a prevalent mental health disorder, is often addressed through conventional methods such as pharmacotherapy and psychotherapy. However, gaps remain in understanding the effectiveness of these treatments compared to alternative approaches, particularly psychospiritual therapies. This paper aims to address these gaps by systematically examining and comparing the most commonly used treatments for depression, including pharmacotherapy, psychotherapy, and Islamic psychospiritual therapy. This study explores the treatment of depression through a comprehensive qualitative content analysis, focusing on the integration of pharmacotherapy, psychotherapy, and Islamic psychospiritual approaches. The findings suggest that integrating Islamic psychospiritual elements can provide a holistic approach to mental health, offering culturally sensitive treatment options that resonate with patients' spiritual and emotional needs, ultimately leading to improved therapeutic outcomes. This study contributes to the growing body of literature advocating for culturally informed mental health care practices that align with patients' beliefs and values.
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