This research aims to examin the mediating effect of institutional support system in the relation between entrepreneurial orientation and women business performance in Iran. This study used quantitative data collected from women entrepreneurs in seven states in Iran. The research samples were selected using purposive samping method. A number of 131 women business owners participated in this study. The data were analysed using SPSS version 24 and SEM version 3. The finding indicated significant influence of entrepreneurial orientation on women business performance. Additionally institutional support system was founded to play a significant role in mediating the relationship between entrepreneurial orientation and business performance. Research implication and recommendation were discussed in this paper.
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