Teachers are the main pillars to give birth to an ingenious generation that can compete globally. This huge responsibility causes teachers to be easily susceptible to anxiety syndrome and depression. Although various past studies conducted varied research on anxiety and depression, there is a need to study the trend of study through these years including the contributors towards these issues. Therefore, this study aims to identify the trend research of anxiety and depression based on the year of publication, research approach, and country context. Moreover, the research would also identify the contributing factors to anxiety and depression among teachers. A total of 31 final articles have been selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model involving four phases which are identification, screening, eligibility, and finally the included stage. The Scopus, SAGE Journal, ERIC, and Google Scholar databases have been used for research based on the most recent 5-year period from 2017 to 2022. The findings show that 2021 is the year where the most articles were published as the research approach used is mainly quantitative. Malaysia is the country that produces the most articles. A total of 4 factors contributing to anxiety and depression among Mathematics teachers were reported such as job aspects (task and teaching knowledge), the Covid-19 epidemic (e-learning), environment (friends), and personal problems (gender). This study provides implications based on teachers' management development aspect whereby counseling and guidance are developed for teachers and school staff. A suggestion for further research that can be carried out by the Malaysian Ministry of Education is by designing an Educator Self-Confidence Intervention Module to strengthen the mental health of teachers at an excellent level.
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