Today’s capabilities, development and true independence of countries have direct relations with large amount of ability to produce and knowledge development. The aim of this study is to evaluate the relative efficiency performance of research and development of Iran in comparison with regional countries using combination mechanism of Data Envelopment Analysis and TOPSIS. Among these research and development activities in fourteen countries in the region has been extracted, in this regard to evaluate the relative efficiency of inputs such as enrollment rates in science and engineering, amount of research and development researchers, research and development expenditure and outputs such as number of scientific and engineering papers, international received patents and export advanced technology. Countries performances in this section were calculated from 49 different input and output combinations and using data envelopment analysis techniques, finally TOPSIS technique were used as a complete ranking mechanism. The ranking results indicate that Lebanon had the best performance and Kyrgyzstan had the weakest performance in total different input and output combinations among selected countries. One of the results which have to be thought is the inadequate position of research and development of Iran among selected countries which ranks thirteen among the 14 countries under study.
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